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A Green Chemical Approach for Iodination of Pyrimidine Derivatives by Mechanical Grinding under Solvent-Free Conditions.
- Source :
-
Molecules . Oct2022, Vol. 27 Issue 19, p6386. 8p. - Publication Year :
- 2022
-
Abstract
- The iodination of pyrimidines is usually carried out by using toxic reagents under acidic conditions, such as with sulfuric acid and nitric acid. To avoid toxic reagents, we developed a simple and eco-friendly approach for the iodination of pyrimidine derivatives under solvent-free conditions using solid iodine and AgNO3 as an electrophilic iodinating reagent. The advantages of this method are the relatively short reaction time (20–30 min), simple set-up procedure, high yields (70–98%), and environmentally friendly reaction conditions. Our novel approach for the iodination of pyrimidines, as well as a variety of their derivatives, will contribute to the development of nucleobase-related drug candidates. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PYRIMIDINE derivatives
*IODINATION
*ELECTROPHILES
*POISONS
*NITRIC acid
*PYRIMIDINES
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 159674519
- Full Text :
- https://doi.org/10.3390/molecules27196386