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Combined Donor-Recipient Obesity and the Risk of Graft Loss After Kidney Transplantation.
- Source :
-
Transplant International . 9/29/2022, Vol. 35, p1-12. 12p. - Publication Year :
- 2022
-
Abstract
- Background: As the prevalence of obesity increases globally, appreciating the effect of donor and recipient (DR) obesity on graft outcomes is of increasing importance. Methods: In a cohort of adult, kidney transplant recipients (2000–2017) identified using the SRTR, we used Cox proportional hazards models to examine the association between DR obesity pairing (body mass index (BMI) >30 kg/m² ), and death-censored graft loss (DCGL) or all-cause graft loss, and logistic regression to examine risk of delayed graft function (DGF) and ≤30 days graft loss. We also explored the association of DR weight mismatch (>30 kg, 10-30 kg (D>R; D<R) and <10 kg (D = R)) with each outcome, stratifying by DR obesity pairing. Results: Relative to non-obese DR, obese DR were highest risk for all outcomes (DCGL: HR 1.26, 95% CI 1.22–1.32; all-cause graft loss: HR 1.09, 95% CI 1.06–1.12; DGF: OR 1.98, 95% CI 1.89–2.08; early graft loss: OR 1.34, 95% CI 1.19–1.51). Donor obesity modified the risk of recipient obesity and DCGL [p = 0.001] and all-cause graft loss [p < 0.001] but not DGF or early graft loss. The known association of DR weight mismatch with DCGL was attenuated when either the donor or recipient was obese. Conclusion: DR obesity status impacts early and late post-transplant outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KIDNEY transplantation
*PROPORTIONAL hazards models
*BODY mass index
Subjects
Details
- Language :
- English
- ISSN :
- 09340874
- Volume :
- 35
- Database :
- Academic Search Index
- Journal :
- Transplant International
- Publication Type :
- Academic Journal
- Accession number :
- 159672372
- Full Text :
- https://doi.org/10.3389/ti.2022.10656