七氟烷联合右美托咪定对腹腔镜下子宫肌瘤切除术患者生命体征、血清 炎性因子和疼痛介质 P 物质、前列腺素 E2 的影响.

Objective:To investigate the effects of sevoflurane combined with dexmedetomidine on vital signs, serum inflammatory factors and pain mediators substance P (SP) and prostaglandin E2 (PGE2) in patients undergoing laparoscopic myomectomy. Methods: A total of 92 patients who underwent elective laparoscopic myomectomy from August 2019 to January 2022 in our hospital were selected. The enrolled patients were divided into control group (46 cases) and study group (46 cases) according to random number table method. The control group received sevoflurane anesthesia, the study group received sevoflurane combined with dexmedetomidine anesthesia. Vital signs, serum inflammatory factors [tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), interleukin-1α (IL-1α)], pain indexes [visual pain analog score (VAS), SP, PGE2], recovery quality and incidence of adverse reactions were compared between the two groups. Results: The heart rate (HR) and mean arterial pressure (MAP) of the study group at 5min after intubation (T1) and after operation (T2) were lower than those of the control group(P<0.05). TNF-α, IL-6 and IL-1βof the study group were lower than those of the control group at 24 h after operation (T3) and 48 h after operation (T4) (P<0.05). VAS, PGE2 and SP of the study group at T3 and T4 were lower than those in the control group (P<0.05). There were no significant differences in recovery time and extubation time between the two groups (P>0.05). The agitation score of the study group was lower than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Sevoflurane combined with dexmedetomidine in laparoscopic myomectomy can reduce postoperative agitation, stabilize hemodynamics, and effectively improve postoperative pain and inflammatory response. [ABSTRACT FROM AUTHOR]