HDAC4 基因多态性与原发性高血压的相关性.

Objective To explore the relationship of histone deacetylase 4（HDAC4） gene rs1108519 and rs3791398 polymorphisms with essential hypertension. Methods Totally 212 patients with essential hypertension were selected, and 212 healthy people were matched as the control group according to the principle of the same sex and age of ±2 years. Sanger sequencing was used to determine the genotype. SPSS22.0 software was used to compare and analyze the relationship of clinical data and gene polymorphisms with essential hypertension. Results（1） Compared with those in the control group, age, BMI, pulse pressure difference, mean arterial pressure, uric acid, triglyceride, RV5, and RV5+SV1 were higher, heart rate was faster, and HDL was lower in hypertension group （all P<0.05）. There was no significant difference in the other clinical data （all P>0.05）.（2） The genotype distribution of the two loci in the two groups were in accordance with Hardy-Weinberg equilibrium （all P>0.05）.Compared with the control group, hypertension group had lower frequencies of genotype AA and allele A in rs1108519 locus, but higher frequencies of genotype AG,GG and allele G （all P<0.05）.There was no significant difference in genotype or allele frequency distribution between the two groups at rs3791398 locus （all P>0.05）.（3） After adjusting for possible confounding, the risk of hypertension in the population with AG and GG genotypes in rs1108519 locus was 5.980 times （OR=5.980,95% CI:1.334-26.811,P=0.019）and 2.832 times （OR=2.832,95% CI:1.466-5.472,P=0.002）that of AA genotype, respectively. Under the dominant model, the risk of hypertension in subjects with AG or GG genotype was 3.207 times higher than that with AA genotype （OR=3.207,95% CI:1.739-5.917,P<0.001）.Under the recessive model, the risk of hypertension in subjects with AG or AA genotype was 19.3% of that with GG genotype （OR=0.193,95% CI:0.045-0.825,P=0.026）.The risk of hypertension in subjects with allele G was 1.816 times higher than that with allele A（OR=1.816,95% CI:1.281-2.575,P=0.001）.There was no significant difference in the risk of hypertension among people with different genotypes and alleles at rs3791398locus（all P>0.05）.Conclusion HDAC4 gene rs1108519locus polymorphism is related to hypertension, and the G allele may be a risk factor for the onset of essential hypertension. [ABSTRACT FROM AUTHOR]