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Paradoxical upgrading reaction following treatment of disseminated tuberculosis-associated haemophagocytic lymphohistiocytosis in an infant without HIV: a case report and review of the literature.
- Source :
-
Paediatrics & International Child Health . May2022, Vol. 42 Issue 2, p78-82. 5p. 2 Color Photographs, 2 Charts. - Publication Year :
- 2022
-
Abstract
- Tuberculosis-associated haemophagocytic lymphohistiocytosis (HLH) is rare in paediatrics and can be fatal if not recognised and treated on time. A 3-month-old infant with tuberculosis and HLH is described. He was successfully treated with anti-tuberculous therapy (ATT) which comprised isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin and dexamethasone (10 mg/m2/day). On Day 28 of therapy, he developed a paradoxical upgrading reaction to ATT for which he was again treated with (oral) corticosteroids for 4 weeks. He recovered successfully and is now completely well and asymptomatic. To the best of our knowledge, this is the first case of a child having a paradoxical upgrading reaction following treatment for TB-HLH. Abbreviations ATT: anti-tuberculous therapy; CB-NAAT: cartridge-based nucleic acid amplification test; CECT: contrast-enhanced computed tomography; HLH: haemophagocytic lymphohistiocytosis; NK: natural killer, PUR: paradoxical upgrading reaction; sHLH: secondary HLH. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20469047
- Volume :
- 42
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Paediatrics & International Child Health
- Publication Type :
- Academic Journal
- Accession number :
- 159632875
- Full Text :
- https://doi.org/10.1080/20469047.2022.2108673