Herpes simplex virus encephalitis in atopic dermatitis patients and responses to dupilumab: A real association or a chance occurrence?

We read with interest about the report from Rao and colleagues of a case of herpes simplex virus (HSV) encephalitis in a 4-year-old girl receiving dupilumab.1 We regard the changes in the type 2 immune response to HSV in atopic dermatitis (AD) patients pre- and post-treatment with dupilumab worthy of further discussion. Keywords: atopic; child; dermatitis; dupilumab; encephalitis; herpes simplex virus EN atopic child dermatitis dupilumab encephalitis herpes simplex virus 848 849 2 10/13/22 20220901 NES 220901 DATA AVAILABILITY STATEMENT Research data are not shared. [Extracted from the article]