In vivo behavior of carboxymethylcellulose based microgels containing 67Cu.

Authors :: Orlova, Marina A.
Spiridonov, Vasiliy V.
Badun, Gennadii A.
Trofimova, Tatiana P.
Orlov, Alexey P.
Zolotova, Alena S.
Priselkova, Anna B.
Aleshin, Gleb Yu.
Chernysheva, Maria G.
Yaroslavov, Alexander A.
Kalmykov, Stepan N.
Source :: Mendeleev Communications. Sep2022, Vol. 32 Issue 5, p658-660. 3p.
Publication Year :: 2022
Abstract: [Display omitted] Using a mouse model, an organ distribution for microgels of carboxymethyl cellulose cross-linked with 67Cu2+ ions was investigated and compared with the distribution of free 67Cu2+ ions from 67CuCl 2. The clearance of the microgels through both liver and kidneys was demonstrated. An additional examination of distribution for [3H]CMC microparticles and [3H]CMC–Cu microgels revealed no copper release from the microgels in vivo. [ABSTRACT FROM AUTHOR]