Protective Effect of Fufang Yatongding on Periodontitis Model Rats.

[Objectives] The paper was to investigate the protective effect of Fufang Yatongding on experimental periodontitis in rats. [Methods] Experimental periodontitis rats were randomly divided into blank group (5 rats), model group, control group and experimental group, with 8 rats in each group. The rats in the blank group were fed with normal diet, and those in the model group, control group and experimental group were administered intragastrically with normal saline, minocycline hydrochloride solution and Fufang Yatongding solution, respectively. After4 weeks, alveolar bone resorption was measured. Serum matrix metalloproteinases (MMPs) and inflammatory factors were detected by ELISA, and the changes in gingival tissue were observed by HE staining. [Results] Compared with the control group, the distance from enamel cementum to alveolar crest in the experimental group was decreased (P <0.05). Compared with the control group, the levels of serum MMPs and inflammatory factors in the experimental group were decreased (P <0.05). The results of HE staining showed that the cells in the gingival tissue of rats in the blank group were normal in morphology and intact in structure, and the cells in the gingival tissue of rats in the model group were damaged and out of order, while the cells in the control group were slightly intact and arranged orderly, and the pathological damage of rats in the experimental group was less than that in the control group. [ Conclusions] Fufang Yatongding has protective effect on experimental periodontitis in rats by inhibiting the release of MMPs and inflammatory factors. [ABSTRACT FROM AUTHOR]