Frequency of various types of gastrointestinal abnormalities in patients with Down's syndrome.

Objective: To assess the frequency of various types of gastrointestinal abnormalities in patients with Down's syndrome. Study Design: Cross Sectional Study. Setting: National Institute of Child Health, Karachi. Period: January 2019 June 2019. Material & Methods: All children with age 1 month to 16 years with Down's syndrome of either gender presented with gastrointestinal signs and symptoms were enrolled. History along with demographic information was obtained from parent and GI examination was done. The outcome variables like duodenal stenosis, gastrophageal reflux, imperforate anus and Hischsprung's disease were noted. Results: The mean age of the children was 8.53+4.07 years. The mean terminal age at the time of delivery was 30.70+3.60 years. The mean number of siblings was 1.08+0.91. Duodenal stenosis was found in 18(6.40%) patients, gastroesophageal reflux was found in 10(3.50%) patients, imperforate anus in 9(3.10%) and Hischsprung's disease was found in 7(2.40%) children. Conclusion: Duodenal stenosis was the most common gastrointestinal (GI) abnormalities found in patients with down's syndrome. [ABSTRACT FROM AUTHOR]