生长分化因子5 在骨关节炎发生发展中的作用.

OBJECTIVE: To explore the role of growth differentiation factor 5 in osteoarthritis and some existing problems, attempting to provide a theoretical basis for the treatment of osteoarthritis. METHODS: Literature related to the role and mechanism of growth differentiation factor 5 in osteoarthritis was searched in CNKI, WanFang, and PubMed databases with “growth differentiation factor 5, articular cartilage, cell migration, cell proliferation, subchondral bone, inflammation, osteoarthritis, rheumatoid arthritis” as Chinese and English search terms, respectively. RESULTS AND CONCLUSION: Growth differentiation factor 5 promotes the differentiation of mesenchymal stem cells into chondrocytes, expresses type II collagen and proteoglycans, and maintains the characteristics of chondrocytes. Growth differentiation factor 5 promotes the hypertrophic differentiation of chondrocytes, but some studies have shown that the expression of chondrocyte hypertrophy markers is reduced after induction with growth differentiation factor 5, indicating that growth differentiation factor 5 is more beneficial than harmful to cartilage repair. Growth differentiation factor 5 can promote steogenesis, increase the mineralization density of subchondral bone, and indirectly promote the repair of cartilage through the repair of subchondral bone. Inflammatory factors are one of the factors that promote the occurrence and development of osteoarthritis. Growth differentiation factor 5 can inhibit the expression of inflammatory factors, thereby protecting against osteoarthritis. As a “multifunctional” inducer, growth differentiation factor 5 has certain effects on cartilage, subchondral bone and inflammation. However, its mechanism of action is still unclear and needs further studies. Overall, growth differentiation factor 5 is expected to be an osteoarthritis-treating drug in the future. [ABSTRACT FROM AUTHOR]