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Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer.
- Source :
-
Dose-Response . Jul2022, Vol. 20 Issue 3, p1-9. 9p. - Publication Year :
- 2022
-
Abstract
- Objective: The aim of this study was to evaluate cell and biochemical biomarkers and establish their prognostic value in patients with advanced laryngeal cancer. Material and Methods: A prospective study included 52 patients with advanced laryngeal carcinoma surgically treated at the tertiary referral center. Tumor tissue was immunohistochemically stained for T-cell markers (CD4 and CD8), and levels of cytokines (IL-6 and IL-8) and C-reactive protein were analyzed from blood samples. Results: Overall 3-year survival (OS) of patients included in the study was 69.2% and the disease specific survival (DSS) 72.5%. Higher expression of CD4+ and CD8+ were significant prognostic factors with positive impact on both OS and DSS in univariate analysis, but not in multivariate analysis. Levels of IL-8 were a significant predictor of 3-year OS and DSS survival in patients with advanced laryngeal cancer but not levels of IL-6 and CRP values. Conclusion: Though high expression of CD4 and CD8 were demonstrated in the tumor tissue, but their prognostic role was not established. Higher values of IL-8 proved to be significant negative predictor of DSS. This could further collaborate the inclusion of combination of biomarkers in assessment of favorable treatment choice in patients with advanced laryngeal carcinoma. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LARYNGEAL cancer
*CANCER patients
*BIOMARKERS
*PROGNOSIS
*OVERALL survival
Subjects
Details
- Language :
- English
- ISSN :
- 15593258
- Volume :
- 20
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Dose-Response
- Publication Type :
- Academic Journal
- Accession number :
- 159437786
- Full Text :
- https://doi.org/10.1177/15593258221115537