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Dynamics of T cells of L3T4 and Ly 2 phenotype within granulomas in murine listeriosis.
- Source :
-
Clinical & Experimental Immunology . Jun1985, Vol. 60 Issue 3, p559-564. 6p. - Publication Year :
- 1985
-
Abstract
- Monoclonal antibodies anti-Ly 1. anti-Ly 2 and GK1.5 were applied to determine phenotypes of T cells within granulomas formed as a result of infection of mice with the facultative intraccllular bacterium Listeria monocytogenes. Early in granuloma formation, equal numbers of Ly 1+ , Ly 2+ and L3T4+ cells were found, T cells of different phenotypes being evenly distributed over the lesions. In mature granulomas, numbers of Ly 1+ and L3T4+ cells about doubled as compared to incipient granulomas, Ly 2+ cells, however, remained constant. Whereas Ly 1+ and L3T4+ cells within mature granulomas still were evenly distributed, Ly 2+ cells were predominantly Iocalized in the periphery of the lesions. The data indicate that both, specific Ly 2+ and L3T4+ T cells, display characteristic dynamics within granulomas: Ly 2+ T cells which most likely mature from Ly 1+2+ T cells over time locate to the periphery. Concomitantly. L3T4+ T cells are enriched maintaining their distribution all over the lesions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 60
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15943650