In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system.

The article reports the In vivo peptide-based delivery of a gene-modifying enzyme into cells of the central nervous system. It describes the mechanism of how Cre delivery activates the expression of a reporter gene in both neurons and astrocytes of the cortex without tissue damage. It mentions the applications of this approach which are beneficial to the transient introduction of proteins into cells in vivo.