COVID-19 Possibly Deteriorates the Conditions of Cancer Patients by Increasing Oxidative Stress.

The extensive spread of COVID-19 all over the world has worried everyone. This pandemic caused by severe acute respiratory syndrome coronavirus 2, which has an envelope and is a positive-sense RNA. The virus causes mild-to-severe signs and symptoms in the patients. The aim of this study is to investigate the relationship between this virus and oxidative stress, which can worsen the conditions of cancer patients through some pivotal pathways. We utilize some international databases using keywords; COVID-19, neoplasm, and reactive oxygen species, and could attain interesting information about neoplasm, COVID-19, and oxidative stress. Based on the research, COVID-19 can induce some crucial routes, such as hypoxia-inducible factor-1a (HIF-1a) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways through overproduction of ROS. Although not proven, it is hypothesized that COVID-19 may enhance oxidative stress by inducing ROS-activated HIF-1a and NF-κB pathways in the cell, which subsequently can have a lot of disturbing effects on the body, and exacerbate the conditions of cancer patients. To conclude, understanding the precise molecular and cellular mechanisms of ROS-dependent HIF-1a and NF-κB pathways in the pathogenesis of COVID-19 can identify greater therapeutic and management strategies for COVID-19-infected cancer patients. [ABSTRACT FROM AUTHOR]