基于EBM 制备钛支架的髋臼缺损支架设计与构建.

Objective To manufacture porous titanium scaffolds by electron beam fusion technology (EBM), and study the design and construction technology of acetabular defect scaffolds. Methods Computeraided design (CAD) was used to design the 3D printed porous samples into 0°/90° orthogonal structures. The 3D-printed acetabular defect scaffold was machined from titanium alloy Ti-6Al-4V powder. The general morphology, fiber diameter and porosity of the scaffolds were measured. The surface element distribution and surface roughness of the scaffolds were observed by energy dispersive X-ray spectrometer (EDS) and scanning electron microscope (SEM), respectively. The load force, deformation and elastic modulus were measured by mechanical test. Computed tomography (CT) scans were performed on patients with acetabular fractures, and the scan data were reconstructed and simulated by mimics software. Results There were no significant differences between the general parameters and microstructure parameters of each stent compared with the design values (P <0. 05). SEM images showed that the scaffold surface was rough, suitable for cell adhesion and bone ingrowth; The mechanical test results showed that the scaffold had good performance, and the elastic modulus values were in the cancellous and cortical bone regions suitable for implantation. Conclusion The combination of CT and CAD reverse technology can complete the design and manufacture of complex bone substitutes, and the finished product has the required microstructure and physical properties. [ABSTRACT FROM AUTHOR]