Viagra: now mending hearts.

Reports on the finding that sildenafil (Viagra) can suppress cardiac hypertrophy and improve heart function in mice exposed to chronic pressure overload. Reversal and normalization of pre-established cardiac enlargement due to pressure overload; Role of cyclic guanylic acid (cGMP) for both membrane-bound guanylate cyclase receptors and for the ubiquitous signaling molecule nitric oxide.