Oral Methylprednisolone and Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy-Reply.

Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy: the TESTING randomized clinical trial. This reduced-dose cohort had a shorter median follow-up duration of 2.5 years, which may have contributed to a larger estimated effect size given the observation that the benefits of methylprednisolone therapy may diminish over the years after treatment is completed. Comment & Response B In Reply b In their Letter about the recent TESTING trial,[1] Drs Ye and Liu point out that previous studies have suggested that individuals of Asian descent may have a worse kidney prognosis than individuals of European descent.[2] However, this does not necessarily mean that the effects of treatment vary by ethnicity. [Extracted from the article]