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Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer.
- Source :
-
Clinical Epigenetics . 9/19/2022, Vol. 14 Issue 1, p1-6. 6p. - Publication Year :
- 2022
-
Abstract
- Lung cancer patients are diagnosed at late stages when curative treatments are no longer possible; thus, molecular biomarkers for noninvasive detection are urgently needed. In this sense, we previously identified and validated an epigenetic 4-gene signature that yielded a high diagnostic performance in tissue and invasive pulmonary fluids. We analyzed DNA methylation levels using the ultrasensitive digital droplet PCR in noninvasive samples in a cohort of 83 patients. We demonstrated that BCAT1 is the candidate that achieves high diagnostic efficacy in circulating DNA derived from plasma (area under the curve: 0.85). Impact of potentially confounding variables was also explored. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18687075
- Volume :
- 14
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Clinical Epigenetics
- Publication Type :
- Academic Journal
- Accession number :
- 159197745
- Full Text :
- https://doi.org/10.1186/s13148-022-01334-3