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Is Melanoma Progression Affected by Thyroid Diseases?
- Source :
-
International Journal of Molecular Sciences . Sep2022, Vol. 23 Issue 17, p10036. 14p. - Publication Year :
- 2022
-
Abstract
- Clinical and epidemiological evidence indicate a relationship between thyroid diseases and melanoma. In particular, the hypothyroidism condition appears to promote melanoma spread, which suggests a protective role of thyroid hormones against disease progression. In addition, experimental data suggest that, in addition to thyroid hormones, other hormonal players of the hypothalamic–pituitary–thyroid (HPT) axis, namely the thyrotropin releasing hormone and the thyrotropin, are likely to affect melanoma cells behavior. This information warrants further clinical and experimental studies in order to build a precise pattern of action of the HPT hormones on melanoma cells. An improved knowledge of the involved molecular mechanism(s) could lead to a better and possibly personalized clinical management of these patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THYROTROPIN releasing factor
*THYROID diseases
*MELANOMA
*THYROID hormones
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 23
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 159011078
- Full Text :
- https://doi.org/10.3390/ijms231710036