Flow imaging using differential Golay encoded ultrasound.

• Differential compression of Golay encoded ultrasound (DCGEU) imaging method is proposed. • Feasibility of slow blood flow imaging in small vessels with the DCGEU is demonstrated. • Complementary Golay coded sequences (CGCS) significantly improves the slow flow imaging. • Transducer bandwidth and high receiving channel noise level influence the slow flow imaging. In our research we present a new method of differential compression of the Golay encoded ultrasound (DCGEU) in the standard beamforming mode to visualize the slow (<1cm/s) blood mimicking fluid flow in small diameter tubes. The proposed DCGEU method is based on synthesis of several subsequent B-mode frames acquired with certain time intervals (30 ms in this study) followed by the visualization of differential beamformed radio frequency (RF) echoes, which yielded the images of the scatterers moving slowly in the vessel and suppressing the static echoes outside the vessel. In order to extract small backscattered echoes from the vessel area we took an advantage of improved sensitivity of the complementary Golay coded sequences (CGCS). The validation of the proposed DCGEU method was carried out in two stages. In the first one, we compared the flow images in small tubes with a diameter of 1 mm and 2.5 mm, reconstructed from numerically simulated acoustic data for the standard transmission of short pulses and 16-bits long CGCS signals. In the second stage of the research, the experimental data were acquired in a flow phantom with silicone tubes with an internal diameter of 1.5 mm and 4.5 mm and a fluid flow velocity of 0.9 cm/s. The experiments were carried out using preprogrammed Verasonics Vantage™ research ultrasound system equipped with ALT L12-5/50 mm MHz linear array transducer with 7.8 MHz center frequency. It was evidenced both in simulations and experiments that the DCGEU provided a good flow image along the entire length of tubing with virtually angle independent detection in comparison with the conventional short pulse interrogation. [ABSTRACT FROM AUTHOR]