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Catalytic asymmetric addition to cyclic N-acyl-iminium: access to sulfone-bearing contiguous quaternary stereocenters.
- Source :
-
Chemical Communications . 9/14/2022, Vol. 58 Issue 71, p9942-9945. 4p. - Publication Year :
- 2022
-
Abstract
- Herein, we report the first chiral phosphoric acid (CPA)-catalyzed asymmetric addition of α-fluoro(phenylsulfonyl)methane (FSM) derivatives to in situ generated cyclic N-acyliminium. This process enables metal-free expeditious access to sulfone and fluorine incorporating contiguous all substituted quaternary stereocenters ingrained in biorelevant isoindolinones in excellent stereoselectivities (up to 99% ee and up to 50 : 1 dr). [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOSPHORIC acid
*STEREOSELECTIVE reactions
*FLUORINE
*SULFONES
*METHANE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 58
- Issue :
- 71
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 158844926
- Full Text :
- https://doi.org/10.1039/d2cc02667h