Back to Search
Start Over
Re-Irradiation for Recurrent Cervical Cancer: A State-of-the-Art Review.
- Source :
-
Current Oncology . Aug2022, Vol. 29 Issue 8, p5262-5277. 16p. 1 Color Photograph, 1 Black and White Photograph, 3 Charts. - Publication Year :
- 2022
-
Abstract
- The recurrence rate of cervical cancer after primary treatment can reach 60%, and a poor prognosis is reported in most cases. Treatment options for the recurrence of cervical cancer mainly depend on the prior treatment regimen and the location of recurrent lesions. Re-irradiation is still considered as a clinical challenge, owing to a high incidence of toxicity, especially in in-field recurrence within a short period of time. Recent advances in radiotherapy have preliminarily revealed encouraging outcomes of re-irradiation. Several centers have concentrasted on stereotactic body radiation therapy (SBRT) for the treatment of well-selected cases. Meanwhile, as the image-guiding techniques become more precise, a better dose profile can also be achieved in brachytherapy, including high-dose-rate interstitial brachytherapy (HDR-ISBT) and permanent radioactive seed implantation (PRSI). These treatment modalities have shown promising efficacy with a tolerable toxicity, providing further treatment options for recurrent cervical cancer. However, it is highly unlikely to draw a definite conclusion from all of those studies due to the large heterogeneity among them and the lack of large-scale prospective studies. This study mainly reviews and summarizes the progress of re-irradiation for recurrent cervical cancer in recent years, in order to provide potential treatment regimens for the management of re-irradiation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11980052
- Volume :
- 29
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Current Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 158749416
- Full Text :
- https://doi.org/10.3390/curroncol29080418