Ratifying frailty.

Taking as a point of departure the role that the category of frailty increasingly plays in the classification, sorting and management of ageing populations in contemporary societies, this paper focuses on the crafting and validation of mouse models of frailty. The paper suggests that such models embody therapeutic and techno-economic expectations of ageing research, particularly as these are re-invigorated by current attempts to manipulate or eradicate cell senescence. The paper brings together critical gerontology, social studies of science and more-than-human anthropology to contextualise and analyse ethnographic data collected during fieldwork in a biology of ageing laboratory. The paper proposes that to build a mouse model of frailty, researchers need to learn to 'think like a mouse', provisionally taking the animal's point of view, to then efface that link and reconfigure the scientific chain of reference that enables translation between humans and mouse models of frailty. • Frailty increasingly plays key role in the classification, sorting and management of ageing populations • Animal models of frailty embody technological promises of 'new geroscience' • Paper identifies two fold process in making and validating mouse models of frailty, involving having to learn to 'think like a mouse', to be able to qualify the model [ABSTRACT FROM AUTHOR]