The Renin-Angiotensin System in Acute Lung Injury.

Acute lung injury, acute respiratory distress syndrome, angiotensin-converting enzyme, renin, angiotensin system, ventilator, induced lung injury 2010; 176:, 2219-2227, 8 Li Y, Zeng Z, Li Y,: Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between angiotensin-converting enzyme and angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation. Keywords: acute lung injury; acute respiratory distress syndrome; angiotensin-converting enzyme; renin; angiotensin system; ventilator; induced lung injury EN acute lung injury acute respiratory distress syndrome angiotensin-converting enzyme renin angiotensin system ventilator induced lung injury 1411 1415 5 08/22/22 20220901 NES 220901 The renin-angiotensin system (RAS) pathway plays key roles in regulating blood pressure, water balance, inflammation, thrombosis, and response to injury. That raises questions about how quickly angiotensin-(1-7) and captopril get into lung tissue and whether there is a dose effect - perhaps there was inadequate dose to alter lung tissue ACE and ACE2 mRNA expression. [Extracted from the article]