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Novel geranylhydroquinone derived meroterpenoids from the fungus Clitocybe clavipes and their cytotoxic activity.
- Source :
-
Fitoterapia . Sep2022, Vol. 161, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- Three novel geranylhydroquinone derived meroterpenoids, named clavilactones J and K (1 – 2) and clavipol C (3), were isolated from the basidiomycete Clitocybe clavipes. Their structures were unambiguously identified by extensive spectroscopic data analysis, and the electronic circular dichroism (ECD) calculation, Gauge-Including Atomic Orbitals (GIAO) NMR calculations and Mo 2 (OAc) 4 -induced electronic circular dichroism experiments were used to establish their absolute configurations. Compound 1 , with two epoxy groups located at the 10-membered carbocycle, is uncommon in the reported meroterpenoids from C. clavipes. All the obtained compounds (1–3) were tested for their cytotoxic activity against human tumor cell line HGC-27 by using the MTT assay. All the compounds exhibited moderate cytotoxic activities against HGC-27 cell with IC 50 values ranging from 33.5 to 56.6 μM. [Display omitted] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 161
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 158540680
- Full Text :
- https://doi.org/10.1016/j.fitote.2022.105251