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Relationship between structure and cytotoxicity of vanadium and molybdenum complexes with pyridoxal derived ligands.
- Source :
-
Journal of Inorganic Biochemistry . Oct2022, Vol. 235, pN.PAG-N.PAG. 1p. - Publication Year :
- 2022
-
Abstract
- In this work four vanadium complexes (compounds 1 , 2 , 3 and 4) and one molybdenum complex (compound 5) with hydrazone ligands derived from pyridoxal were synthesized and characterized. All compounds are mononuclear species, two of them (compounds 3 and 5) are dioxide complexes and the other three (compounds 1 , 2 and 4) monoxide complexes. The vanadium atom of the compound 3 is five-coordinated and all the other compounds have a six coordinated environment polyhedron. The poses for the potential intercalation of the compounds 2 and 3 with DNA were obtained by using AutoDock software. Optimizations were also performed at PM6-D3H4 semi-empirical level whereas the study of the nature of the interaction was carried out by means of the Energy Decomposition Analysis and the Non-Covalent Interaction index by using in both cases Density Functional Theory computations. The cytotoxicity in lung cancer cells (A549 cell line) of all the compounds was also evaluated. After 24 h of treatment, vanadium complexes showed high values of IC 50 , between 419.93 ± 22.58 and 685.88 ± 46.55 μM. After 48 h, the results showed that the compound 3 had the lowest IC 50 value, 65.32 ± 9.95 μM, and the compound 2 the highest value, 375.28 ± 32.09 μM. The molybdenum complex showed the lowest IC 50 value at 48 h (11.22 ± 1.34 μM). The toxicity of the compounds 3 , 4 and 5 was tested in vivo , using zebrafish model, and the molybdenum complex showed higher toxic effects than the studied vanadium complexes. [Display omitted] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01620134
- Volume :
- 235
- Database :
- Academic Search Index
- Journal :
- Journal of Inorganic Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 158515505
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2022.111937