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Relationship between structure and cytotoxicity of vanadium and molybdenum complexes with pyridoxal derived ligands.

Authors :
Mato-López, Lucía
Sar-Rañó, Antía
Fernández, Miguel Riopedre
Díaz-Prado, María Luz
Gil, Adrià
Sánchez-González, Ángel
Fernández-Bertólez, Natalia
Méndez, Josefina
Valdiglesias, Vanessa
Avecilla, Fernando
Source :
Journal of Inorganic Biochemistry. Oct2022, Vol. 235, pN.PAG-N.PAG. 1p.
Publication Year :
2022

Abstract

In this work four vanadium complexes (compounds 1 , 2 , 3 and 4) and one molybdenum complex (compound 5) with hydrazone ligands derived from pyridoxal were synthesized and characterized. All compounds are mononuclear species, two of them (compounds 3 and 5) are dioxide complexes and the other three (compounds 1 , 2 and 4) monoxide complexes. The vanadium atom of the compound 3 is five-coordinated and all the other compounds have a six coordinated environment polyhedron. The poses for the potential intercalation of the compounds 2 and 3 with DNA were obtained by using AutoDock software. Optimizations were also performed at PM6-D3H4 semi-empirical level whereas the study of the nature of the interaction was carried out by means of the Energy Decomposition Analysis and the Non-Covalent Interaction index by using in both cases Density Functional Theory computations. The cytotoxicity in lung cancer cells (A549 cell line) of all the compounds was also evaluated. After 24 h of treatment, vanadium complexes showed high values of IC 50 , between 419.93 ± 22.58 and 685.88 ± 46.55 μM. After 48 h, the results showed that the compound 3 had the lowest IC 50 value, 65.32 ± 9.95 μM, and the compound 2 the highest value, 375.28 ± 32.09 μM. The molybdenum complex showed the lowest IC 50 value at 48 h (11.22 ± 1.34 μM). The toxicity of the compounds 3 , 4 and 5 was tested in vivo , using zebrafish model, and the molybdenum complex showed higher toxic effects than the studied vanadium complexes. [Display omitted] [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01620134
Volume :
235
Database :
Academic Search Index
Journal :
Journal of Inorganic Biochemistry
Publication Type :
Academic Journal
Accession number :
158515505
Full Text :
https://doi.org/10.1016/j.jinorgbio.2022.111937