泊沙康唑的合成、检测及其临床应用研究进展.

Posaconazole， as the second generation of triazole antifungal drugs， has a wide antifungal spectrum and strong antibacterial activity. It is widely used in clinical practice. However， it has been eight years since its publication before it is approved in China. In order to better understand posaconazole， a first-line drug with great clinical demand， this paper summarizes the pharmacokinetics， pharmacological properties， clinical application and synthetic route of posaconazole in the literature at home and abroad. It is hoped that it can fill the gap in the domestic API market， break the current situation that the API is completely dependent on import， and provide a useful reference for the industrial R ＆ D. [ABSTRACT FROM AUTHOR]