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Crystalline structures of l-cysteine and l-cystine: a combined theoretical and experimental characterization.
- Source :
-
Amino Acids . Aug2022, Vol. 54 Issue 8, p1123-1133. 11p. - Publication Year :
- 2022
-
Abstract
- It is assumed that genetic diseases affecting the metabolism of cysteine and the kidney function lead to two different kinds of pathologies, namely cystinuria and cystinosis whereby generate l-cystine crystals. Recently, the presence of l-cysteine crystal has been underlined in the case of cystinosis. Interestingly, it can be strikingly seen that cystine ([–S–CH2–CH–(NH2)–COOH]2) consists of two cysteine (C3H7NO2S) molecules connected by a disulfide (S–S) bond. Therefore, the study of cystine and cysteine is important for providing a better understanding of cystinuria and cystinosis. In this paper, we elucidate the discrepancy between l-cystine and l-cysteine by investigating the theoretical and experimental infrared spectra (IR), X-ray diffraction (XRD) as well as Raman spectra aiming to obtain a better characterization of abnormal deposits related to these two genetic pathologies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09394451
- Volume :
- 54
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Amino Acids
- Publication Type :
- Academic Journal
- Accession number :
- 158447157
- Full Text :
- https://doi.org/10.1007/s00726-022-03144-6