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A Phage Display Derived Cyclized Peptide Inhibits Fibrosarcoma Cells Invasion via Suppression of MMP-9 Activity.
- Source :
-
International Journal of Peptide Research & Therapeutics . Sep2022, Vol. 28 Issue 5, p1-11. 11p. - Publication Year :
- 2022
-
Abstract
- Matrix metalloproteinases (MMPs) play critical roles in the invasiveness of cancerous cells and metastasis of solid tumors. MMP-9 is a member of this protease family, which is extremely overexpressed in metastatic cells. Here, we described a cyclic peptide which inhibits the MMP-9 activity with high potency. This inhibitor selectively binds to the MMP-9 fibronectin domain and interferes with the interaction of gelatinous substrates with MMP-9, thereby suppressing its gelatinolytic activity. Previously, we isolated and developed a linear peptide, named as RSH-12, from a phage display library which displayed promising results in the inhibition of MMP-9. Next, we decided to improve its biostability via cyclization chemistry and show that RSH-12 has a considerably enhanced stability in human serum. Moreover, the cyclic peptide is still associated with a high potency to inhibit the invasion activity of a human fibrosarcoma cell line. These results demonstrate that the designed cyclic peptide might be considered as a promising therapeutic moiety to target the MMP-9 for the treatment of cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15733149
- Volume :
- 28
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- International Journal of Peptide Research & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 158377052
- Full Text :
- https://doi.org/10.1007/s10989-022-10446-6