Hippo/YAP 参与肝纤维化发生发展的作用机制.

Various etiologies cause the destruction of liver microenvironment, which leads to the loss of liver structure and function and initi-ates the process of liver fibrosis. Hepatic stellate cells ( HSCs) are mainly activated into myofibroblasts that secrete a large amount of extra-cellular matrix ( ECM), mostly collagen. Although there have been many studies on the anti - liver fibrosis mechanism, there is still a lack of effective target drugs for clinical application, and in recent years, studies on anti - liver fibrosis have mainly focused on interventions for the advanced stage of liver fibrosis, while ignoring the specific mechanism of early - stage liver fibrosis. Recently, there have been an in-creasing number of studies on Hippo signaling in liver fibrosis, with a focus on the expression of the core transcription factor Yes - associated protein ( YAP) in early activated HSCs and the regulation of HSC status by this pathway. This article mainly introduces the role of the Hippo/YAP pathway in the regulation of early - stage or advanced liver fibrosis and briefly describes the potential role of regulating the stable expression and nuclear translocation of the core transcription factor YAP in reversing liver fibrosis, suggesting that this pathway can provide new directions and targets for clinical treatment. [ABSTRACT FROM AUTHOR]