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Effectiveness of early exercise on reducing skeletal muscle loss during preoperative neoadjuvant chemotherapy for esophageal cancer.
- Source :
-
Surgery Today . Aug2022, Vol. 52 Issue 8, p1143-1152. 10p. - Publication Year :
- 2022
-
Abstract
- Purpose: To investigate if early exercise can help prevent skeletal muscle loss and improve the clinical outcomes of esophageal cancer patients receiving preoperative neoadjuvant chemotherapy (NAC). Methods: This was a single-center, retrospective observational cohort study of 110 patients with advanced esophageal cancer. We analyzed the effect of early exercise on the risk of skeletal muscle loss (defined as > 2.98%) during NAC and the subsequent clinical outcomes. Patients in the early exercise group (n = 71) started exercise therapy 8 days earlier than those the late exercise group (n = 39). Results: The median age of the patients was 65.4 years, the mean BMI was 21.1 kg/m2, and 92 (84%) of the 110 patients were men. Skeletal muscle loss occurred in 34% and 67% of the early and late exercise groups, respectively (p < 0.001). There was a lower risk of surgical site infection in the early exercise group (1% vs 16%, p = 0.021). Multivariate analysis revealed that early exercise reduced the risk of skeletal muscle loss (OR = 0.25, 95% CI 0.09–0.65, p = 0.006). Conclusions: Our results suggest that early exercise reduces the risk of both skeletal muscle loss during NAC and subsequent surgical site infection in patients with esophageal cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09411291
- Volume :
- 52
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Surgery Today
- Publication Type :
- Academic Journal
- Accession number :
- 158137771
- Full Text :
- https://doi.org/10.1007/s00595-021-02449-5