Mechanosynthesis of Sulfanilamide Matrix Forms.

The possibility of obtaining polymer–drug conjugates as prolonged-action antibacterial systems by mechanochemical synthesis using the copolymer of maleic anhydride with vinyl acetate or oxidized potato starch as polymer matrices and sulfanilamide as the antimicrobial drug was studied. It is established that drug conjugation with the polymer results from covalent bonding, the degree of sulfanilamide conversion depends on the magnitude of active force and the time of the solid-phase reaction, and the product continues to accumulate after the load is removed. The conjugate with the polysaccharide matrix, from which the drug release due to cleavage of an azomethine bond was slower than its removal from the body if the initial dosage form was used, was most promising. [ABSTRACT FROM AUTHOR]