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RuO2/rGO heterostructures as mimic peroxidases for colorimetric detection of glucose.
- Source :
-
Microchimica Acta . Jul2022, Vol. 189 Issue 7, p1-10. 10p. - Publication Year :
- 2022
-
Abstract
- The successful synthesis of ruthenium oxide/reduced graphene oxide (RuO2/rGO) heterostructures by one-pot hydrothermal method using graphene oxides and RuCl3 as precursors is reported. The heterostructures had high peroxidase-like (POD-like) activities, which catalyzes the oxidation of classical peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2 to create a blue colored reaction product. The catalytic activity was significantly enhanced by the synergistic effect between RuO2 nanoparticles and rGO. RuO2/rGO had a low Km of 0.068 mM and a high vmax of 1.228 × 10−7 M·s−1 towards TMB in the TMB-H2O2 catalytic oxidation system. In addition, the POD-like activity originating from the electron transfer mechanism was confirmed by cytochrome C (Cyt C) oxidation experiment. A colorimetric method based on RuO2/rGO heterostructures was developed with good sensitivity and selectivity for glucose detection with a limit of detection of 3.34 μM and a linear range of 0–1500 μM. The RuO2/rGO heterostructures have potential applications in the biomedical areas, such as biosensor and diagnostics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00263672
- Volume :
- 189
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Microchimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 158060750
- Full Text :
- https://doi.org/10.1007/s00604-022-05319-0