替雷利珠联合白蛋白紫杉醇治疗晚期肺癌的疗效分析 及对 T 细胞亚群的影响.

Objective: To study the efficacy of tislelizumab combined with albumin paclitaxel in the treatment of advanced lung cancer, and to explore its effect on T cell subsets. Methods: 80 patients with advanced lung cancer who were treated in the hospital from July 2018 to October 2021 were selected and divided into monotherapy group and joint group according to different treatment methods, with 40 cases in each group. The monotherapy group received albumin paclitaxel treatment, and the joint group received tisleli beads combined with albumin. To compare the clinical efficacy, adverse reactions, serum IgA and IgG levels before and posttreatment, and peripheral blood CD4+ and CD8+ T cell subsets between the two groups of patients. Results: (1) The clinical treatment effective rate of patients in the joint group was 87.5 %, which was higher than the clinical treatment effective rate of 67.5 % in the monotherapy group (P<0.05); (2) Liver and kidney damage, vomiting, fatigue, and leukopenia in the two groups of patients posttreatment There was no difference in the incidence of adverse reactions such as neurotoxicity and hand-foot syndrome(P>0.05); (3) Serum IgA and IgG of patients in the joint group posttreatment were higher than those in the monotherapy group(P<0.05); (4) Study posttreatment, the ratio of CD4+ and CD4+ /CD8+ T lymphocytes in the group was higher than that of the monotherapy group (P<0.05), while the ratio of CD8+ T lymphocytes was lower than that of the monotherapy group (P<0.05). Conclusion: The treatment of tisleli beads combined with albumin paclitaxel can significantly improve the clinical treatment efficiency of patients with advanced lung cancer, but does not increase the incidence of adverse reactions, and can effectively improve the immune function of patients. [ABSTRACT FROM AUTHOR]