Back to Search Start Over

The Small Heat Shock Protein, HSPB1, Interacts with and Modulates the Physical Structure of Membranes.

Authors :
Csoboz, Balint
Gombos, Imre
Kóta, Zoltán
Dukic, Barbara
Klement, Éva
Varga-Zsíros, Vanda
Lipinszki, Zoltán
Páli, Tibor
Vígh, László
Török, Zsolt
Source :
International Journal of Molecular Sciences. Jul2022, Vol. 23 Issue 13, p7317-N.PAG. 12p.
Publication Year :
2022

Abstract

Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and modulate the physical state of membranes across species. Through these interactions, sHSPs contribute to the maintenance of membrane integrity. HSPB1 is a major sHSP in mammals, but its lipid interaction profile has so far been unexplored. In this study, we characterized the interaction between HSPB1 and phospholipids. HSPB1 not only associated with membranes via membrane-forming lipids, but also showed a strong affinity towards highly fluid membranes. It participated in the modulation of the physical properties of the interacting membranes by altering rotational and lateral lipid mobility. In addition, the in vivo expression of HSPB1 greatly affected the phase behavior of the plasma membrane under membrane fluidizing stress conditions. In light of our current findings, we propose a new function for HSPB1 as a membrane chaperone. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
23
Issue :
13
Database :
Academic Search Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
157995738
Full Text :
https://doi.org/10.3390/ijms23137317