Can We Always Trust the Wisdom of the Body?

Permissive hypercapnia ([9]) and, in some cases, mild, graded permissive hypoxemia ([10]) appear to be well-tolerated alternatives to otherwise noxious intrusions, such as ventilation with high levels of airway driving pressure and inspired oxygen. Keywords: critical illness; homeostatic control; homeostasis EN critical illness homeostatic control homeostasis 1268 1271 4 07/18/22 20220801 NES 220801 THE CONCEPT AND RANGE OF HOMEOSTASIS A wide range of physical demands characterizes the activities of daily life. Neither patient nor physician may know all the relevant particulars - patient self-induced lung injury as well as ventilator-induced lung injury (VILI) are equally possible at every stage ([2], [3]). The appropriate hierarchy of signals may be disrupted by acute disease or sensory inputs to the controller may be out of balance, and it is almost certain that the "vulnerability" of lung tissue is not "hard wired" into the native control system. [Extracted from the article]