OKSIDATIVNI STRES I PREEKLAMPSIJA.

Preeclampsia (PE) is the most common form of hypertensive disorder in pregnancy, affecting 2–7% of pregnant women worldwide. The complex pathophysiology of preeclampsia begins with abnormal placental development, and immunologic aberrations. Rheological consequences of impaired conversion of spiral arteries result in the placenta’s oxidative stress and disturbed production and the role of placental factors such as the pro and antiangiogenic factor, VEGF, and PIGF, and sFLT1 (soluble fms-like tyrosine kinase 1). This shift in production is partially mediated by epigenetics. [ABSTRACT FROM AUTHOR]