İdrar Kültürlerinden İzole Edilen Bakteriler ve Çeşitli Antibiyotiklere Karşı Direnç Durumları.

Objective: Urinary tract infections (UTI) are the most common among the community and hospital-acquired infections. Escherichia coli is the most frequently isolated microorganism in UTIs. The treatment is mostly empirical. However, resistance related to the inappropriate use of antibiotics causes problems. Therefore, determining regional antibiotic resistance profiles and regular surveillance is essential. Therefore, we aimed to evaluate the distribution of strains and their resistance patterns isolated from urine samples at our laboratory. Methods: The results of urine samples sent to our laboratory between January 1, 2018, and December 31, 2018, were analyzed retrospectively. Conventional methods and the automatized device performed identification and antimicrobial susceptibility of the isolates. Results: Significant bacterial growth was detected in 2331(14.1%) of 16 521 urine samples, and 2051 were included in the study. The most frequently isolated strain was E. coli (70.4%). The resistance rate was highest for ampicillin (61.4%) among the bacteria that belong to the Enterobacteriaceae family. The most susceptible antibiotics were fosfomycin, imi-penem, and meropenem, respectively. Pseudomonas aeruginosa and Acinetobacter spp. were found to have multidrug resistance. ESBL positivity was 19.3%. Among ESBL positive strains, the highest resistance rates were against ampicillin (98.2%). All the Enterococcus spp. isolates were susceptible to linezolid. All the S. saprophyticus isolates were susceptible to ciprofloxacin, linezolid, vancomycin, teicoplanin, and trimethoprim-sulfamethoxazole. All S. agalactiae strains were susceptible to penicillin, vancomycin, teicoplanin, and linezolid. Conclusion: Pathogens responsible for urinary tract infections and antibiotic resistance rates differ among inpatients and outpatients. Therefore, it is essential to identify UTI agents, perform antibiotic susceptibility tests, and conduct surveillance studies at hospitals and regional levels to guide successful empirical treatment of in-and-outpatients. [ABSTRACT FROM AUTHOR]