Asymmetric syntheses of (–)-hedyosumins A–C via enantioselective Diels–Alder reaction of (E)-Hex-3-en-5-yn-2-one and platinum(II)-catalyzed [3+2]-cyclization.

[Display omitted] Enantioselective construction of the central [3.2.1] oxa-bicyclic core of hedyosumins A–C was achieved via an enantioselective Diels–Alder reaction and a platinum(II)-catalyzed 1,3-dipolar [3+2] cycloaddition as key steps, which leads to the asymmetric total synthesis of hedyosumins A-C. [ABSTRACT FROM AUTHOR]