Back to Search Start Over

Adjuvant Transarterial Chemoembolization for Patients with Intrahepatic Cholangiocarcinoma after Surgical Resection: A Systematic Review and Meta-analysis.

Authors :
Lang Wang
Xiaoling Wen
Liping Zhuang
Kewei Fang
Jiang Shen
Source :
Journal of Gastrointestinal & Liver Diseases. Jun2022, Vol. 31 Issue 2, p215-222. 8p.
Publication Year :
2022

Abstract

Aim: To investigate the efficacy of postoperative adjuvant transarterial chemoembolization (TACE) in patients with intrahepatic cholangiocarcinoma (ICC) after resection. Methods: Studies were systematically searched until August 2021 in the following databases: MEDLINE, EMBASE, PUBMED, Web of Science, Cochrane Library, Science Direct, and Springer Link. Overall survival (OS) and recurrence-free survival (RFS) were considered as the main outcomes. Pooled hazard ratio (HR) with 95% confidence interval (95%CI) was reported as results for the survival data. Subgroup analysis was conducted on the outcomes stratified by early-stage ICC and intra-arterial chemotherapeutic regimen. Results: Eleven studies with 2,757 patients were finally included in the study. The pooled HR of OS was 0.68 (95%CI: 0.50-0.87, I²=83.7%). The pooled HR of RFS was 1.00 (95%CI: 0.69-1.31, I²=88%). Receipt of postoperative adjuvant TACE improved the OS in the early-stage ICC subgroup (HR=0.68, 95%CI: 0.50-0.86, I²=54%). Addition of carboplatin could slightly improve the OS (HR=0.6, 95%CI: 0.35-0.85, I²=48%). But receipt of postoperative adjuvant TACE (HR=1.06, 95%CI: 0.83-1.29, I²=41.2%) or use of carboplatin (HR=1.30, 95%CI: 0.93-1.67, I²=0%) caused no significant improvement in the RFS in the early-stage ICC subgroup. Conclusions: Postoperative adjuvant TACE could improve the OS in ICC patients after hepatectomy but could not prevent late recurrence. Survival benefit was also found in early-stage ICC patients undergoing postoperative adjuvant TACE after hepatectomy. Addition or non-addition of carboplatin in chemoembolization showed a similar OS outcome. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18418724
Volume :
31
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Gastrointestinal & Liver Diseases
Publication Type :
Academic Journal
Accession number :
157828913
Full Text :
https://doi.org/10.15403/jgld-4207