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Non-Productive Infection of Glial Cells with SARS-CoV-2 in Hamster Organotypic Cerebellar Slice Cultures.
- Source :
-
Viruses (1999-4915) . Jun2022, Vol. 14 Issue 6, pN.PAG-N.PAG. 16p. - Publication Year :
- 2022
-
Abstract
- The numerous neurological syndromes associated with COVID-19 implicate an effect of viral pathogenesis on neuronal function, yet reports of direct SARS-CoV-2 infection in the brain are conflicting. We used a well-established organotypic brain slice culture to determine the permissivity of hamster brain tissues to SARS-CoV-2 infection. We found levels of live virus waned after inoculation and observed no evidence of cell-to-cell spread, indicating that SARS-CoV-2 infection was non-productive. Nonetheless, we identified a small number of infected cells with glial phenotypes; however, no evidence of viral infection or replication was observed in neurons. Our data corroborate several clinical studies that have assessed patients with COVID-19 and their association with neurological involvement. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SARS-CoV-2
*COVID-19
*HAMSTERS
*VIRUS diseases
*INFECTION
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 14
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Viruses (1999-4915)
- Publication Type :
- Academic Journal
- Accession number :
- 157823979
- Full Text :
- https://doi.org/10.3390/v14061218