Back to Search
Start Over
Value of Thyroid Peroxidase Antibodies in Neuroimmune Diseases: Analysis of Interference During Treatment with Intravenous Immunoglobulins.
- Source :
-
Laboratory Medicine . Jul2022, Vol. 53 Issue 4, p426-432. 7p. - Publication Year :
- 2022
-
Abstract
- Objective The absence of specific markers can make the diagnosis of neuroimmune disorders difficult, making other biomarkers such as thyroid peroxidase antibodies (TPO-Abs) more relevant. Laboratory tests are susceptible to interference, especially those tests performed using immunoassay techniques. The effect of treatment with human intravenous immunoglobulin (IVIG) on the results of TPO-Abs assays has not been previously characterized. Materials and Methods We analyzed TPO-Abs levels in 170 children monitored in the neuroimmune disease department of a tertiary hospital. We analyzed the characteristics of patients with increased TPO-Abs values and compared their progress with and without treatment. Results We found that 97% of patients with elevated TPO-Abs had received IVIG. After withdrawal from IVIG, a mean TPO-Abs decrease of 62.5% at 1 month was observed. The IVIG drug preparation was found to contain 1176 U/mL of TPO-Abs. An interferogram confirmed interference. Conclusion It is advisable to measure levels of TPO-Abs before starting immunotherapy and remain vigilant regarding possible interference in the event of unsubstantiated elevations of this analyte. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIOMARKERS
*CLINICAL pathology
*THYROTROPIN
*AUTOANTIBODIES
*IMMUNOGLOBULINS
*NEUROLOGICAL disorders
*THYROXINE
*TERTIARY care
*RETROSPECTIVE studies
*MANN Whitney U Test
*FISHER exact test
*IMMUNOASSAY
*T-test (Statistics)
*BLOOD sedimentation
*DESCRIPTIVE statistics
*CHI-squared test
*OXIDOREDUCTASES
*IMMUNOLOGIC diseases
*TRIIODOTHYRONINE
*DATA analysis software
*LONGITUDINAL method
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 00075027
- Volume :
- 53
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 157794372
- Full Text :
- https://doi.org/10.1093/labmed/lmac013