Effect of statins combined or not combined with metformin on polycystic ovary syndrome: A systematic review and meta‐analysis.

Background: This meta‐analysis was conducted to evaluate the effect of statins combined or not combined with metformin on polycystic ovary syndrome (PCOS). Methods: Databases were systematically searched from inception to February 2022. Meta‐analysis was conducted by using STATA 12.0 software. In the study, standard mean difference (SMD) and 95% confidence intervals (CI) were computed as the effect size. A random effect model was used. Results: Meta‐analysis showed significant decline of total testosterone, free testosterone, dehydroepiandrosterone sulphate, androstenedione, luteinizing hormone (LH), LH to follicle‐stimulating hormone (FSH) ratio, and prolactin in statin group. Our study also demonstrated significant decline of total cholesterol, low‐density lipoprotein cholesterol, and triglycerides in statin group. Moreover, we found significant decline of fasting glucose, insulin sensitivity index, and high‐sensitivity C‐reactive protein. Conclusion: The meta‐analysis showed that statin therapy was good for women with PCOS, and could improve clinical signs of PCOS. [ABSTRACT FROM AUTHOR]