Data-driven contact network models of COVID-19 reveal trade-offs between costs and infections for optimal local containment policies.

While several non-pharmacological measures have been implemented for a few months in an effort to slow the coronavirus disease (COVID-19) pandemic in the United States, the disease remains a danger in a number of counties as restrictions are lifted to revive the economy. Making a trade-off between economic recovery and infection control is a major challenge confronting many hard-hit counties. Understanding the transmission process and quantifying the costs of local policies are essential to the task of tackling this challenge. Here, we investigate the dynamic contact patterns of the populations from anonymized, geo-localized mobility data and census and demographic data to create data-driven, agent-based contact networks. We then simulate the epidemic spread with a time-varying contagion model in ten large metropolitan counties in the United States and evaluate a combination of mobility reduction, mask use, and reopening policies. We find that our model captures the spatial-temporal and heterogeneous case trajectory within various counties based on dynamic population behaviors. Our results show that a decision-making tool that considers both economic cost and infection outcomes of policies can be informative in making decisions of local containment strategies for optimal balancing of economic slowdown and virus spread. • Data-driven contact network models are developed to learn social contact network patterns in COVID-19. • The model simulates the epidemic spread with a time-varying contagion model in ten large metropolitan counties in the United States. • The model is capable of evaluating the effectiveness of combinations of mobility reduction, mask use, and reopening policies. • A decision-making tool is provided for making decisions for optimal balancing of economic slowdown and virus spread. [ABSTRACT FROM AUTHOR]