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Emerging Targets for the Treatment of Osteoarthritis: New Investigational Methods to Identify Neo-Vessels as Possible Targets for Embolization.
- Source :
-
Diagnostics (2075-4418) . Jun2022, Vol. 12 Issue 6, p1403. 11p. - Publication Year :
- 2022
-
Abstract
- Osteoarthritis (OA) is the major cause of disability, affecting over 30 million US adults. Continued research into the role of neovascularization and inflammation related to osteoarthritis in large-animal models and human clinical trials is paramount. Recent literature on the pathogenetic model of OA has refocused on low-level inflammation, resulting in joint remodeling. As a result, this has redirected osteoarthritis research toward limiting or treating joint changes associated with persistent synovitis. The overall goal of this review is to better understand the cellular and tissue-specific mechanisms of inflammation in relation to a novel OA treatment modality, Genicular Artery Embolization (GAE). This article also assesses the utility and mechanism of periarticular neovascular embolization for the treatment of OA with a particular emphasis on the balance between pro-angiogenic and anti-angiogenic cytokines, inflammatory biomarkers, and imaging changes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OSTEOARTHRITIS
*SYNOVITIS
*THERAPEUTICS
*ADDUCTION
*CLINICAL trials
*INFLAMMATION
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 12
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Diagnostics (2075-4418)
- Publication Type :
- Academic Journal
- Accession number :
- 157715054
- Full Text :
- https://doi.org/10.3390/diagnostics12061403