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Elucidating structural patterns in hydrogen bond dense materials: a study of ammonium salts of (4‐aminium‐1‐hydroxybutylidine)‐1,1‐bisphosphonic acid.
- Source :
-
Zeitschrift für Anorganische und Allgemeine Chemie . 6/27/2022, Vol. 648 Issue 12, p1-10. 10p. - Publication Year :
- 2022
-
Abstract
- The syntheses and structures of ammonium salts of the active pharmaceutical agent (4‐aminium‐1‐hydroxybutylidine)‐1,1‐bisphosphonic acid (alendronic acid, LH5) have been examined. Three deprotonation states of the parent acid were achieved i. e. LH4−, LH32− and LH23−, and crystallisation gave a total of six different structural phases including [NH4][LH4] ⋅ 2(H2O) as two polymorphs 1 a and 1 b, two hydrates of [NH4]2[LH3] ⋅ x(H2O), x=3 (2), x=6 (3), [NH4]5[LH3][LH2] ⋅ 8(H2O) (4) and [NH4]3[LH2] ⋅ 3(H2O) (5). The crystal structures obtained, along with that of the parent acid, enable a direct comparison of competing supramolecular synthons, involving phosphonate‐phosphonate O−H⋅⋅⋅O and ammonium‐phosphonate N−H⋅⋅⋅O hydrogen bonds, in a series displaying progressively decreasing P‐OH with concomitantly increasing RNH3+ moieties. Indeed, the structures show some consistent connectivity patterns of the alendronate units, which thus assemble into substructures such as 2‐D sheets (LH5 ⋅ H2O, 1 a), zig‐zag chains (2, 5) or ladder‐like arrays (3, 4). The occurrence of these motifs appears to correlate with the ionisation level of the parent acid. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AMMONIUM salts
*HYDROGEN bonding
*ALENDRONIC acid
*ACIDS
*CRYSTAL structure
Subjects
Details
- Language :
- English
- ISSN :
- 00442313
- Volume :
- 648
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Zeitschrift für Anorganische und Allgemeine Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 157665920
- Full Text :
- https://doi.org/10.1002/zaac.202100305