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Stereodefined Skipped Dienes through Iridium‐Catalyzed Formal Addition of Tertiary Allylic C−H Bonds to Alkynes.
- Source :
-
Angewandte Chemie International Edition . 6/27/2022, Vol. 61 Issue 26, p1-7. 7p. - Publication Year :
- 2022
-
Abstract
- Preparation of skipped dienes with a quaternary carbon center at the C‐3 position remains a synthetic challenge. We report here an iridium‐catalyzed formal addition of tertiary sp3 C−H bond to alkyne for the facile preparation of skipped dienes. The tertiary allylic C−H bond is cleaved regioselectively, at the site of which a new C−C bond is formed. Enantioselective construction of acyclic quaternary carbon stereocenters is also demonstrated. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIOLEFINS
*ALKYNES
*ALKENES
*CARBON
*ISOMERIZATION
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 61
- Issue :
- 26
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 157549286
- Full Text :
- https://doi.org/10.1002/anie.202200075