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Stereodefined Skipped Dienes through Iridium‐Catalyzed Formal Addition of Tertiary Allylic C−H Bonds to Alkynes.

Authors :
Wang, Zi‐Xuan
Gao, Peng‐Chao
Lin, En‐Ze
Li, Bi‐Jie
Source :
Angewandte Chemie International Edition. 6/27/2022, Vol. 61 Issue 26, p1-7. 7p.
Publication Year :
2022

Abstract

Preparation of skipped dienes with a quaternary carbon center at the C‐3 position remains a synthetic challenge. We report here an iridium‐catalyzed formal addition of tertiary sp3 C−H bond to alkyne for the facile preparation of skipped dienes. The tertiary allylic C−H bond is cleaved regioselectively, at the site of which a new C−C bond is formed. Enantioselective construction of acyclic quaternary carbon stereocenters is also demonstrated. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14337851
Volume :
61
Issue :
26
Database :
Academic Search Index
Journal :
Angewandte Chemie International Edition
Publication Type :
Academic Journal
Accession number :
157549286
Full Text :
https://doi.org/10.1002/anie.202200075