Blood Pressure Response to Strength Training May Be Influenced by Angiotensinogen A–20C and Angiotensin II Type I Receptor A1166C Genotypes in Older Men and Women.

To determine the influence of angiotensinogen (AGT) A–20C, M235 T, and angiotensin II type 1 receptor (AGTR1) A1166C genotypes on resting blood pressure (BP) response to strength training (ST) in older men and women.Prospective intervention study with retrospective genotyping.University of Maryland Exercise Physiology Laboratory.Seventy sedentary, healthy older men (n=34) and women (n=36).Approximately 23 weeks of ST performed 3 days per week.Resting BP was measured on six separate occasions before and after ST for each subject. AGT and AGTR1 genotyping was performed retrospectively from each subject's genomic deoxyribonucleic acid.Systolic BP decreased in C-allele carriers at the AGT A–20C locus with ST (122±1 to 116±2 mmHg,P<.05), which was significantly greater than the decrease in the A homozygotes (126±1 to 123±1 mmHg,P<.05). At the AGTR1 A1166C locus, diastolic BP decreased to a greater extent in the C-allele carriers (76±1 to 70±2 mmHg,P<.05) than in the A homozygotes (75±1 to 72±1 mmHg,P<.05).The AGT A–20C and AGTR1 A1166C genotypes may influence resting BP response to ST, such that C-allele carriers at each of these loci reduce their resting BP in response to ST to a greater extent than A homozygotes. [ABSTRACT FROM AUTHOR]