Thrombotic microangiopathies (PE/HELLP, TTP, aHUS). Differential diagnosis: clinical and laboratory features.

The causes of thrombotic microangiopathy (TMA), identified during pregnancy, are varied: pregnancy-specific and not specific. The differentiation between a severe preeclampsia/HELLP syndrome (hemolysis, elevated liver enzymes, low platelets), thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS) may be challenging but is critical to ensure the correct management of the pregnant patient as well for future pregnancies, and to institute promptly the treatment, as these are acute conditions with significant morbidity and mortality in untreated patients. [ABSTRACT FROM AUTHOR]