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Circulating Cell-Free Mitochondrial DNA in Pregnancy.

Authors :
Bradshaw, Jessica L.
Cushen, Spencer C.
Phillips, Nicole R.
Goulopoulou, Styliani
Source :
Physiology. Jul2022, Vol. 37 Issue 4, p187-196. 10p.
Publication Year :
2022

Abstract

Circulating cell-free mitochondrial DNA (ccf-mtDNA) released upon cell injury or death stimulates diverse pattern recognition receptors to activate innate immune responses and initiate systemic inflammation. In this review, we discuss the temporal changes of ccf-mtDNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*CELL-free DNA
*PREGNANCY outcomes
*PREGNANCY complications
*PATTERN perception receptors
*PREGNANCY

Details

Language :
English
ISSN :
15489213
Volume :
37
Issue :
4
Database :
Academic Search Index
Journal :
Physiology
Publication Type :
Academic Journal
Accession number :
157483275
Full Text :
https://doi.org/10.1152/physiol.00037.2021
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